Premenstrual Syndrome (PMS)

Home » Premenstrual Syndrome (PMS) » Causes

Causes

Scientists have been unable to identify a single cause of PMS. Theories range from hormonal and chemical to nutritional and psychological. Women whose mother or sisters have PMS are more likely to have it, so there may be a genetic component. A combination of genetic, physiological, and environmental causes are likely.

Hormones and neurochemicals
The physical, emotional, and psychological changes that occur in PMS coincide with hormonal changes of the menstrual cycle. PMS may be a response to declining levels of estrogen and progesterone that occur just prior to menstruation. The exact role of the various hormones are not clear. Some neurochemicals (chemicals that help make up the nervous system) also have been implicated. Hormones and neurochemicals may interact to produce PMS.

Mineralocorticoids are a group of hormones that regulate the body'’s fluids and electrolytes (e.g., sodium, potassium). Changing levels of mineralocorticoids may cause the bloated feeling that is common in women with PMS.

Prolactin stimulates breast development and the formation of milk during pregnancy and is associated with amenorrhea (abnormal absence of menstruation) and other gynecologic complications. Excess prolactin may cause the breast tenderness associated with PMS, although studies show that suppressing the secretion of excess prolactin does not relieve symptoms.

Prostaglandins are hormonelike substances that play a role in the luteal phase of the menstrual cycle, which occurs prior to bleeding. Changing levels of prostaglandins may be involved in PMS.

Serotonin and gamma-aminobutyric acid (GABA) are chemicals that relay signals from one nerve cell to the next (neurotransmitters). Low levels of serotonin have been linked to depression, and low levels of GABA are associated with anxiety, both symptoms of PMS.

Endorphins are neurochemicals that suppress pain and increase the threshold to painful stimuli. Low levels of endorphins may be involved in PMS.

Nutrition
Nutrition probably plays a causal role in PMS. Women can alleviate many symptoms by changing their diet. Eliminating certain foods or drinks often reduces symptoms to more tolerable levels.

Hypoglycemia (low blood sugar) afflicts many PMS sufferers. Some researchers speculate that the hypoglycemia is a precursor to PMS.

Depression
Because depression-related symptoms are prevalent in women who suffer PMS, there may be an underlying psychological condition that causes or contributes to PMS. Approximately 60% of women with major affective disorder (e.g., depression) also have PMS, and more than 30% of women who suffer chronic depression experience their first depressive episode during a time of significant hormonal change (e.g., premenstrually). In one study, between 57% and 100% of women who suffered PMS were found to have had at least one prior major depressive episode, compared to 0% to 20% of women without PMS.

However, PMS encompasses more than depression, and by focusing too much on this aspect, other important physiological factors may be overlooked.

Premenstrual Syndrome (PMS), Causes reprinted with permission from womenshealthchannel.com
© 1998-2008 Healthcommunities.com, Inc. All Rights Reserved.

Premenstrual Syndrome (PMS) Resources

	Join Our PMS Forum Do you have a question, want to share medical advice, or just need to discuss your situation with someone else having a similar experience? The healthchannels forum is a resource for everyone to share and discuss their health and medical needs with others.	Advertising Disclaimer
	Living with...Share your story Do you have a personal health story that you would like to share with others? As a source of free patient education, our goal is to provide our users with trustworthy information and support from others. That's why we've started our "Living with..." sections.
	Our "Living With..." support pages are a place to share experiences about living with a certain condition, disease, disorder, or illness and for loved ones of those dealing with health-related issues. Many people, especially when newly diagnosed, find comfort in knowing that others are having a similar experience. Help others by sharing your story. View stories already submitted.
	Stay Updated Sign up for our newsletter and receive important updates on the medical conditions that are most important to you.
To quickly access health information from your website's browser, download Healthcommunities.com's healthchannels toolbar. Advertising Disclaimer